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1

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

Takami Tomiyama, Tetsu Nagata, Hiroyuki Shimada, Rie Teraoka, Akiko Fukushima, Hyoue Kanemitsu, Hiroshi Takuma, Ryozo Kuwano, Masaki Imagawa, Suzuka Ataka, Yasuhiro Wada, Eito Yoshioka, Tomoyuki Nishi

Journal:

Annals of Neurology

Year:

2008

Language:

english

File:

PDF, 756 KB

english, 2008

2

Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes

Sébastien S Hébert, Chantal Godin, Takami Tomiyama, Hiroshi Mori, Georges Lévesque

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 353 KB

english, 2003

3

Regulation of cholesterol efflux by amyloid β secretion

Tomohiro Umeda, Hiroshi Mori, Hui Zheng, Takami Tomiyama

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 41 KB

english, 2010

4

Neurodegenerative Disorder FTDP-17–Related Tau Intron 10 +16C→T Mutation Increases Tau Exon 10 Splicing and Causes Tauopathy in Transgenic Mice

Umeda, Tomohiro, Yamashita, Takenari, Kimura, Tetsuya, Ohnishi, Kiyouhisa, Takuma, Hiroshi, Ozeki, Tomoko, Takashima, Akihiko, Tomiyama, Takami, Mori, Hiroshi

Journal:

The American Journal of Pathology

Year:

2013

Language:

english

File:

PDF, 8.42 MB

english, 2013

5

Regulation of tau exon 10 splicing by a double stem–loop structure in mouse intron 10

Takenari Yamashita, Takami Tomiyama, Qiang Li, Hideharu Numata, Hiroshi Mori

Journal:

Year:

2005

Language:

english

File:

PDF, 234 KB

english, 2005

6

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

Umeda, Tomohiro, Maekawa, Satomi, Kimura, Tetsuya, Takashima, Akihiko, Tomiyama, Takami, Mori, Hiroshi

Journal:

Acta Neuropathologica

Year:

2014

Language:

english

File:

PDF, 1.27 MB

english, 2014

7

Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome

Hiroshi Mori, Takami Tomiyama, Naoki Maeda, Kazuharu Ozawa, KenIchi Wakasa

Journal:

Year:

2003

Language:

english

File:

PDF, 318 KB

english, 2003

8

The preclinical safety evaluation of human monoclonal antibody against cytomegalovirus

Keiko Matsuzawa, Tamotsu Koyama, Shigeki Sugawara, Sunao Ikegawa, Satoshi Asano, Satoshi Sasaki, Takami Tomiyama, Yoshinori Kasahara, Yoshiaki Okamiya, Kyoko Inoue, Tomohiro Ohta, Tokutaro Makita

Journal:

Fundamental and Applied Toxicology

Year:

1992

Language:

english

File:

PDF, 850 KB

english, 1992

9

Hypercholesterolemia accelerates memory impairment in a transgenic mouse model of Abeta oligomers

Erika Kitajima, Tomohiro Umeda, Toshiki Idomoto, Mary P. Lambert, William L. Klein, Takami Tomiyama, Hiroshi Mori

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 45 KB

english, 2010

10

Intranasal rifampicin for Alzheimer's disease prevention

Umeda, Tomohiro, Tanaka, Akiko, Sakai, Ayumi, Yamamoto, Akira, Sakane, Toshiyasu, Tomiyama, Takami

Journal:

Alzheimer s & Dementia Translational Research & Clinical Interventions

Year:

2018

Language:

english

File:

PDF, 2.32 MB

english, 2018

11

Structure–activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain

Masahiro Ono, Miyuki Hori, Mamoru Haratake, Takami Tomiyama, Hiroshi Mori, Morio Nakayama

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 483 KB

english, 2007

12

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

Kazuchika Nishitsuji, Takami Tomiyama, Kenichi Ishibashi, Kazuhiro Ito, Rie Teraoka, Mary P. Lambert, William L. Klein, Hiroshi Mori

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 1.37 MB

english, 2009

13

Intraneuronal accumulation of Aβ oligomers causes abnormal tau phosphorylation, glial activation and neuronal loss in transgenic mice with APP E693Δ mutation

Takami Tomiyama, Tomohiro Umeda, Naomi Sakama, Mary P. Lambert, William L. Klein, Hiroshi Mori

Journal:

Alzheimer's & Dementia

Year:

2010

Language:

english

File:

PDF, 65 KB

english, 2010

14

P4-258: Amyloid imaging of a patient with Alzheimer's disease harboring a novel APP mutation (E693Δ)

Shimada, Hiroyuki, Tomiyama, Takami, Ataka, Suzuka, Wada, Yasuhiro, Yoshioka, Eito, Miki, Takami, Watanabe, Yasuyoshi, Mori, Hiroshi

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

15

The Medical Student's Class Guide.

Shimada, Hiroyuki, Tomiyama, Takami, Ataka, Suzuka, Wada, Yasuhiro, Yoshioka, Eito, Miki, Takami, Watanabe, Yasuyoshi, Mori, Hiroshi

Journal:

Year:

1886

File:

PDF, 849 KB

1886

16

P3-072: QUANTITATIVE MEASUREMENT OF AMYLOID BETA OLIGOMER IN MOUSE BRAIN USING DOT BLOT ASSAY

Amano, Akiko, Sanjo, Nobuo, Nakakido, Makoto, Tsumoto, Kouhei, Matsubara, Etsuro, Nishida, Yoichiro, Hattori, Takaaki, Nagata, Tetsuya, Tomiyama, Takami, Yokota, Takanori

Journal:

Alzheimer's & Dementia

Year:

2019

File:

PDF, 162 KB

2019

17

A microneutralization enzyme immunoassay for antibody to human cytomegalovirus

Takami Tomiyama, Toru Sugano, Shinobu Tani, Kenji Hosoda, Yoh-ichi Matsumoto

Journal:

Journal of Immunological Methods

Year:

1993

Language:

english

File:

PDF, 576 KB

english, 1993

18

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice

Umeda, Tomohiro, Eguchi, Hiroshi, Kunori, Yuichi, Matsumoto, Yoichi, Taniguchi, Taizo, Mori, Hiroshi, Tomiyama, Takami

Journal:

Annals of Clinical and Translational Neurology

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

19

Redescription ofBassozetus compressus(Günther 1878), a senior synonym ofBassozetus elongatusSmith and Radcliffe 1913 (Ophidiiformes: Ophidiidae)

Tomiyama, Shinichi, Takami, Munehiro, Fukui, Atsushi

Journal:

Ichthyological Research

Year:

2016

Language:

english

File:

PDF, 725 KB

english, 2016

20

Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy

Ichimura, Koichi, Fukushima, Shintaro, Totoki, Yasushi, Matsushita, Yuko, Otsuka, Ayaka, Tomiyama, Arata, Niwa, Tohru, Takami, Hirokazu, Nakamura, Taishi, Suzuki, Tomonari, Fukuoka, Kohei, Yanagisawa,

Journal:

Acta Neuropathologica

Year:

2016

Language:

english

File:

PDF, 1.39 MB

english, 2016

21

Rivastigmine Improves Appetite by Increasing the Plasma Acyl/Des-Acyl Ghrelin Ratio and Cortisol in Alzheimer Disease

Furiya, Yoshiko, Tomiyama, Takami, Izumi, Tesseki, Ohba, Naoki, Ueno, Satoshi

Journal:

Dementia and Geriatric Cognitive Disorders Extra

Year:

2018

Language:

english

File:

PDF, 470 KB

english, 2018

22

Proteomic analysis of the brain tissues from a transgenic mouse model of amyloid β oligomers

Masaoki Takano, Kouji Maekura, Mieko Otani, Keiji Sano, Tooru Nakamura-Hirota, Shogo Tokuyama, Kyong Son Min, Takami Tomiyama, Hiroshi Mori, Shogo Matsuyama

Journal:

Neurochemistry International

Year:

2012

Language:

english

File:

PDF, 640 KB

english, 2012

23

GUIDELINE FOR THE USE OF PLATELET TRANSFUSION CONCENTRATES BASED ON SCIENTIFIC EVIDENCE

Takami, Akiyoshi, Matsushita, Tadashi, Ogata, Masao, Fujii, Nobuharu, Hato, Takaaki, Tomiyama, Yoshiaki, Kubuki, Yoko, Mizuta, Shuichi, Kohno, Takehiro, Matsuzaki, Koji, Yonemura, Yuji, Matsumoto, Mas

Journal:

Japanese Journal of Transfusion and Cell Therapy

Year:

2017

File:

PDF, 509 KB

2017

24

A transgenic mouse model of amyloid β oligomers: Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo

Takami Tomiyama, Shogo Matsuyama, Hiroyuki Iso, Hiroshi Takuma, Tomohiro Umeda, Kiyouhisa Ohnishi, Rie Teraoka, Kenichi Ishibashi, Kazuchika Nishitsuji, Kazuhiro Ito, David R. Borchelt, Mary P. Lamber

Journal:

Alzheimer's & Dementia

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

25

The Preclinical Safety Evaluation of Human Monoclonal Antibody against Cytomegalovirus

MATSUZAWA, KEIKO, KOYAMA, TAMOTSU, SUGAWARA, SHIGEKI, IKEGAWA, SUNAO, ASANO, SATOSHI, SASAKI, SATOSHI, TOMIYAMA, TAKAMI, KASAHARA, YOSHINORI, OKAMIYA, YOSHIAKI, INOUE, KYOKO, OHTA, TOMOHIRO, MAKITA, T

Journal:

Toxicological Sciences

Year:

1992

Language:

english

File:

PDF, 1.77 MB

english, 1992

26

A new deepwater assfish, Bassozetus nielseni sp. nov. (Ophidiiformes: Ophidiidae), from the North Atlantic and West Indian oceans

Tomiyama, Shinichi, Takami, Munehiro, Fukui, Atsushi

Journal:

Ichthyological Research

Year:

2018

Language:

english

File:

PDF, 1.83 MB

english, 2018

27

Absence of synaptophysin near cortical neurons containing oligomer Aβ in Alzheimer's disease brain

Ken-Ichi Ishibashi, Takami Tomiyama, Kazuchika Nishitsuji, Mitsuhiro Hara, Hiroshi Mori

Journal:

Journal of Neuroscience Research

Year:

2006

Language:

english

File:

PDF, 190 KB

english, 2006

28

Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease

Honjo, Yasuyuki, Ayaki, Takashi, Tomiyama, Takami, Horibe, Tomohisa, Ito, Hidefumi, Mori, Hiroshi, Takahashi, Ryosuke, Kawakami, Koji

Journal:

Year:

2017

Language:

english

File:

PDF, 407 KB

english, 2017

29

Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation

Naruhiko Sahara, Takami Tomiyama, Hiroshi Mori

Journal:

Journal of Neuroscience Research

Year:

2000

Language:

english

File:

PDF, 701 KB

english, 2000

30

A new deepwater assfish,Bassozetusmozambiquensissp. nov. (Ophidiiformes: Ophidiidae), from the western Indian Ocean

Tomiyama, Shinichi, Takami, Munehiro, Fukui, Atsushi

Journal:

Ichthyological Research

Year:

2017

Language:

english

File:

PDF, 896 KB

english, 2017

31

APP Osaka Mutation in Familial Alzheimerâs DiseaseâIts Discovery, Phenotypes, and Mechanism of Recessive Inheritance

Tomiyama, Takami, Shimada, Hiroyuki

Journal:

International Journal of Molecular Sciences

Year:

2020

Language:

english

File:

PDF, 2.89 MB

english, 2020

32

The domestic cat as a natural animal model of Alzheimer’s disease

Chambers, James K., Tokuda, Takahiko, Uchida, Kazuyuki, Ishii, Ryotaro, Tatebe, Harutsugu, Takahashi, Erika, Tomiyama, Takami, Une, Yumi, Nakayama, Hiroyuki

Journal:

Acta Neuropathologica Communications

Year:

2015

Language:

english

File:

PDF, 4.66 MB

english, 2015

33

Regulation of cholesterol efflux by amyloid β secretion

Tomohiro Umeda, Hiroshi Mori, Hui Zheng, Takami Tomiyama

Journal:

Journal of Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 632 KB

english, 2010

34

Rifampicin is a candidate preventive medicine against amyloid β and tau oligomers

Umeda, Tomohiro, Ono, Kenjiro, Sakai, Ayumi, Yamashita, Minato, Mizuguchi, Mineyuki, Klein, William L., Yamada, Masahito, Mori, Hiroshi, Tomiyama, Takami

Journal:

Year:

2016

Language:

english

File:

PDF, 2.09 MB

english, 2016

35

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects β-amyloid peptide production

SUGA, Kei, TOMIYAMA, Takami, MORI, Hiroshi, AKAGAWA, Kimio

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 537 KB

english, 2004

36

Proteomic analysis involved with synaptic plasticity improvement by GABAA receptor blockade in hippocampus of a mouse model of Alzheimerâs disease

Kadoyama, Keiichi, Matsuura, Kenji, Takano, Masaoki, Otani, Mieko, Tomiyama, Takami, Mori, Hiroshi, Matsuyama, Shogo

Journal:

Neuroscience Research

Year:

2020

File:

PDF, 3.76 MB

2020

37

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of βAPP in neuronal cells

Kei Suga, Ayako Saito, Takami Tomiyama, Hiroshi Mori, Kimio Akagawa

Journal:

Journal of Neurochemistry

Year:

2005

Language:

english

File:

PDF, 492 KB

english, 2005

38

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Tomohiro Umeda, Takami Tomiyama, Naomi Sakama, Saya Tanaka, Mary P. Lambert, William L. Klein, Hiroshi Mori

Journal:

Journal of Neuroscience Research

Year:

2011

Language:

english

File:

PDF, 3.54 MB

english, 2011

39

Recognition of human immunodeficiency virus glycoproteins by natural anti-carbohydrate antibodies in human serum

Takami Tomiyama, Douglas Lake, Yasuhiko Masuho, Evan M. Hersh

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 1.28 MB

english, 1991

40

Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice

Matsuyama, Shogo, Teraoka, Rie, Mori, Hiroshi, Tomiyama, Takami

Journal:

Year:

2007

Language:

english

File:

PDF, 116 KB

english, 2007

41

Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models

Ohshima, Yoichi, Taguchi, Katsutoshi, Mizuta, Ikuko, Tanaka, Masaki, Tomiyama, Takami, Kametani, Fuyuki, Yabe-Nishimura, Chihiro, Mizuno, Toshiki, Tokuda, Takahiko

Journal:

Year:

2018

Language:

english

File:

PDF, 721 KB

english, 2018

42

Intraneuronal amyloid-beta oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Umeda, Tomohiro, Tomiyama, Takami, Sakama, Naomi, Tanaka, Saya, Lambert, Mary, Klein, William, Mori, Hiroshi

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 50 KB

english, 2011

43

Distinct functions of tau isoforms in Alzheimer's disease

Hiroshi Mori, Satoru Kosaka, Shigeki Arawaka, Takami Tomiyama

Journal:

International Congress Series

Year:

2003

Language:

english

File:

PDF, 121 KB

english, 2003

44

Clinical Course of Patients with Familial Early-Onset Alzheimer’s Disease Potentially Lacking Senile Plaques Bearing the E693Δ Mutation in Amyloid Precursor Protein

Shimada, Hiroyuki, Ataka, Suzuka, Tomiyama, Takami, Takechi, Hajime, Mori, Hiroshi, Miki, Takami

Journal:

Dementia and Geriatric Cognitive Disorders

Year:

2011

Language:

english

File:

PDF, 810 KB

english, 2011

45

E22Δ Mutation in Amyloid β -Protein Promotes β -Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

Suzuki, Takayuki, Murakami, Kazuma, Izuo, Naotaka, Kume, Toshiaki, Akaike, Akinori, Nagata, Tetsu, Nishizaki, Tomoyuki, Tomiyama, Takami, Takuma, Hiroshi, Mori, Hiroshi, Irie, Kazuhiro

Journal:

International Journal of Alzheimer's Disease

Year:

2011

Language:

english

File:

PDF, 1.77 MB

english, 2011

46

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice

Tomohiro Umeda, Takami Tomiyama, Erika Kitajima, Toshiki Idomoto, Sachiko Nomura, Mary P. Lambert, William L. Klein, Hiroshi Mori

Journal:

Year:

2012

Language:

english

File:

PDF, 1.86 MB

english, 2012

47

Corrigendum

Umeda, Tomohiro, Tomiyama, Takami, Sakama, Naomi, Tanaka, Saya, Lambert, Mary, Klein, William, Mori, Hiroshi

Journal:

Year:

1992

File:

PDF, 31 KB

1992

48

O4-06-08: Identification and characterization of a novel APP mutation (E693Δ) in familial Alzheimer's disease

Takami Tomiyama, Tetsu Nagata, Hiroshi Takuma, Hiroyuki Shimada, Rie Teraoka, Akiko Fukushima, Hyoue Kanemitsu, Ryozo Kuwano, Masaki Imagawa, Suzuka Ataka, Yasuhiro Wada, Eito Yoshioka, Tomoyuki Nishi

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 58 KB

english, 2008

49

Preparation of human monoclonal antibodies against a cytomegalovirus glycoprotein complex of 130 and 55 kDa

Takami Tomiyama, Yoh-ichi Matsumoto, Tohru Sugano, Shigeki Fujinaga, Yusuhiko Masuho

Journal:

Journal of Immunological Methods

Year:

1990

Language:

english

File:

PDF, 561 KB

english, 1990

50

Oligomeric Amyloid β -Protein as a Therapeutic Target in Alzheimers Disease: Its Significance Based on its Distinct Localization and the Occurrence of a Familial Variant Form

Ito, Kazuhiro, Ishibashi, Ken-Ichi, Tomiyama, Takami, Umeda, Tomohiro, Yamamoto, Kei-Ichi, Kitajima, Erika, Idomoto, Toshiki, Nagatomo, Toshie, Mori, Hiroshi

Journal:

Current Alzheimer Research

Year:

2009

Language:

english

File:

PDF, 295 KB

english, 2009

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